Experiential Boundaries

Using an analysis of the door’s semantic, utilitarian and its protective potential as provocations and triggers, [Von Meiss, 1998], this proposal will explore doors long history as a strategic boundary device used to control points of entry, egress, or indeed exclusion to a city or inner sanctuary. However, the scenarios which unfold on the door are seldom used to examine the experiential relationships between people, objects and environments in a way which challenges the marketing strategies, and commercial contexts associated with markets and customer satisfaction. The door remains the architectural micro-site of serendipitous social interactions, transactions and occasional transgressions and psychological threshold seen, increasingly in exclusive, security conscious, gated-communities whose technological dependency reveals anxieties of containment and encroachment. Smith and Topham (2012) described this as communities whose experiential encounters are closed-off from others and unwittingly pave the way for domestic designs that imprison free inhabitants in alarmed paradises. This contradiction opens up the experiential aspects of the door to the concept of doubleness recalling Van Eyck’s of the doors two faces -inside or out, raising interesting questions of what one would design first -its inner domestic face or outer defensive skin and as plane(s) in which the world reverses suggesting a new, emergent anatomy and a language for the doorway. Florida State University Department of Interior Architecture & Design; PARADE (Publication & Research in Art, Architectures, Design and Environments); the interdisciplinary research organisation AMPS (Architecture, Media, Politics, Society) and its academic journal Architecture_MPS

2,7-Diazabicyclo[2.2.1]heptanes:novel asymmetric access and controlled bridge-opening

La presente investigación está orientada a identificar el impacto que tuvo Cultura PE en los medios digitales, el proyecto fue elaborado, planificado y puesto en marcha con el apoyo del área de Marketing de la Universidad de San Martin de Porres. Cultura PE se llevó a cabo en las calles de Lima, logrando ser conocido y reconocido por la difusión que se le dio en distintos medios, siendo el de mayor impacto el medio digital, en la plataforma de Facebook, con el respaldo de la USMP. El estudio es de enfoque mixto, cuantitativo por cuanto se realizó una encuesta y cualitativo por el análisis de los procesos en el desarrollo del proyecto; es descriptivo, correlacional y explicativo. La muestra con la que contó fue de egresados de la USMP. En esta tesis se demostró que la presencia digital, inversión publicitaria y un contenido de valor pueden cambiar la perspectiva que un usuario tiene frente a una marca, como fue el caso Cultura PE que tuvo impacto la imagen de marca de la USMP

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)

© 2017 Thomas et al. Background: The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to standard care) for the management of eczema in children with moderate to severe disease. Methods and findings: This was a parallel-group, randomised, controlled, observer-blind trial. Children aged 1 to 15 y with moderate to severe eczema were recruited from secondary care and the community at five UK medical centres. Participants were allocated using online randomisation (1:1) to standard care or to standard care plus silk garments, stratified by age and recruiting centre. Silk garments were worn for 6 mo. Primary outcome (eczema severity) was assessed at baseline, 2, 4, and 6 mo, by nurses blinded to treatment allocation, using the Eczema Area and Severity Index (EASI), which was log-transformed for analysis (intention-to-treat analysis). A safety outcome was number of skin infections. Three hundred children were randomised (26 November 2013 to 5 May 2015): 42% girls, 79% white, mean age 5 y. Primary analysis included 282/300 (94%) children (n = 141 in each group). The garments were worn more often at night than in the day (median of 81% of nights [25th to 75th centile 57% to 96%] and 34% of days [25th to 75th centile 10% to 76%]). Geometric mean EASI scores at baseline, 2, 4, and 6 mo were, respectively, 9.2, 6.4, 5.8, and 5.4 for silk clothing and 8.4, 6.6, 6.0, and 5.4 for standard care. There was no evidence of any difference between the groups in EASI score averaged over all follow-up visits adjusted for baseline EASI score, age, and centre: adjusted ratio of geometric means 0.95, 95% CI 0.85 to 1.07, (p = 0.43). This confidence interval is equivalent to a difference of −1.5 to 0.5 in the original EASI units, which is not clinically important. Skin infections occurred in 36/142 (25%) and 39/141 (28%) of children in the silk clothing and standard care groups, respectively. Even if the small observed treatment effect was genuine, the incremental cost per quality-adjusted life year was £56,811 in the base case analysis from a National Health Service perspective, suggesting that silk garments are unlikely to be cost-effective using currently accepted thresholds. The main limitation of the study is that use of an objective primary outcome, whilst minimising detection bias, may have underestimated treatment effects. Conclusions: Silk clothing is unlikely to provide additional benefit over standard care in children with moderate to severe eczema. Trial registration: Current Controlled Trials ISRCTN77261365